Matano replaces, Sammy Pamzo Omollo, who has since joined Oserian after he was sacked on Wednesday 15 August, following a string of poor results.
Confirming the news to futaa.com, Matano said that is yet to discuss the contract's terms with the Brewers.
-I am now a Tusker Coach. I will be meeting them to discuss the terms of the contract.
-It's a good to be back to coaching, he said.
His first assignment at the Ruaraka-based side will be against Ulinzi Stars FC, on Monday 27 August, in Nairobi.
Matano, who will be deputized by George Maina, won the league with Batoto Ba Mungu on their debut in 2009 before joining AFC Leopards the following year.